Diabetes as secondary cause in Hyperlipidemia

It has long been known that the most common lipoprotein alteration among diabetic patients is hypertriglyceridemia. Plasma triglyceride elevation is directly related to decreased lipoprotein lipase activity. Mixed dyslipidemias are also common in diabetic individuals. It is worth calling attention to the abnormalities related to low-density lipoprotein cholesterol (LDL-c) particles. The treatment of dyslipidemia in diabetic individuals begins with measures aimed at adequate control of the underlying disease. Normalization of glycemic levels is often sufficient to correct Iipid changes. Diabetes control involves some non-pharmacological measures that are common to the treatment of dyslipidemias: diet and physical exercise (both related to the improvement in insulin resistance). Dietary guidance aims to adjust the daily caloric intake, so that the individual reaches and/or maintains adequate weight, and changes in the distribution of carbohydrates, proteins and fats in the diet, in order to provide satisfactory control of glycemic and lipid levels. Therefore, the introduction or adjustment of previous doses of oral hypoglycemic agents or insulin is necessary. If lipid levels remain high after adequate glycemic control and adherence to the proposed lifestyle modifications (diet, regular physical exercise...), we must rule out other causes of secondary dyslipidemia before indicating lipid-lowering drugs. The most commonly used medications in diabetic individuals are HMG[1]CoA reductase inhibitors and fibric acid derivatives.

Diabetes as secondary cause in Hyperlipidemia

Rabelo LM, Rabelo MM, Saldanha ALR, Margeotto APP, Gasparoto ALV and Martinez TLR  Diabetes as secondary cause in Hyperlipidemia